Efficacy and Safety of Viagra® (Sildenafil Citrate) in Men With…

Erectile dysfunction (ED) is a precondition with a high figure in patients with cardiovascular disease (CVD) due to several factors.
The same risk factors (diabetes, evaporation, and hypertension) are implicated in the pathogenesis of both diseases.
In arithmetic operation, certain drugs used in the handling of CVD may induce ED ( eg, thiazide diuretics, digoxin, and beta blockers).

Aim

The aim of this reflexion, which was presented at the Scientific Sessions of the 49th Habitant Educational institution of Cardiology association was the human action of the efficacy and contraceptive device of sildenafil for the discussion of ED in patients with CVD.

Methods

A amount of 224 men with ED and CVD, who were not under nitrate therapy, were randomized to either sildenafil (n=136) or medicament (n=88) in this 12-week, double-blind study; 83% of the men had hypertension, 19% had previous myocardial infarction; 17% had coronary arteria disease, 17% had inflammatory disease, 14% had previous coronary main road, 12% had peripheral vascular disease, and 5% had congestive intuition destiny.

The dose of viagra was started at 50 mg, which could be adjusted to 100 mg or 25 mg based on efficacy and tolerability.
The drug was taken approximately 1 hour before sexual bodily function, not more than once daily, 10 clock time per calendar month on statistic.

The efficacy of the attention was assessed using Proposal 3 (Q3; cognition to achieve erections) and Uncertainty 4 (Q4; cognition to maintain erections) of the International Exponent of Erectile Software (IIEF).
The answers were then graded on a measuring instrument of 1 (almost never/never) to 5 (almost always/always).

Results

viagra direction significantly improved erectile map in men with CVD and ED.
The mean success for Marriage proposal 3 (ability to achieve erections) increased from 1.8 +/- 0.14 at touchstone to 3.9 +/- 0.16 (P < .0001) in week 12 in patients receiving cheap sildenafil citrate in likeness to a thing of 2.2 +/- 0.19 to 2.4 +/- 0.19 in the vesper radical.
Accordingly, the mean incision for Topic 4 (ability to maintain erections) increased from 1.5 +/- 0.12 at criterion to 3.5 +/- 0.18 (P < .0001) in week 12 in patients receiving sildenafil in examination to a happening of 1.6 +/- 0.14 to 2.1 +/- 0.21 in the vesper building block.
The product of patients reporting an shift of their erections was significantly higher in the viagra abstraction (71% vs 24% in the vesper group).

The most common adverse events were flushing (17% of viagra, 2% placebo), concern (15% viagra, 1% placebo), and dyspepsia (4% sildenafil, 0% placebo), with nearly all of these organism mild or moderate.
Ten patients (7%) in the viagra set and 8 patients (9%) in the medicine radical discontinued treatment; only 1 semantic role discontinued because of an adverse consequence (placebo group), the others because of lack of efficacy.
Four patients (3%) in the sildenafil grouping and 2 patients (2%) in the medication abstract entity had serious adverse events, but none were considered by the investigators to be communicating related.

Selection

The authors conclude that oral viagra is an effective and well-tolerated communication for ED in patients with CVD who are not taking nitrate therapy.

Patients in the viagra intervention abstraction had significant increases in their abilities to achieve and to maintain erections.
The adverse events were mild to moderate in causal agent, and besides flushing, no adverse events were deemed to be direction related.

Input

This subject has shown that viagra is well tolerated in patients with cardiovascular disease who are not taking nitrate therapy and is thus in concord with previous studies.
Nevertheless, it has to be used with circumspection, particularly in certain semantic role groups that have not been sufficiently studied, such as patients with unstable heart disease, congestive pith omission, stroking, or uncontrolled hypertension, or in patients after an acute myocardial infarction, among others.
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